That's a really interesting question actually
In my opinion, people that overconsume any media, like games, animes and movies/series can end up breaking the barrier between these 2 and end up thinking of the real world like if it was the media they like
A good example are the beauty patterns in general, people use really beautiful women and really muscular man with beautiful hairs and eyes to think of a model of a man or a woman, and the same way it can happen with stuff that aren't real, like anime
Actually, people get way too used to stuff they end up seeing on popular media and can end up adapting it to real life, i think there's a limit of where this confusion is safe or not, like, i personally don't see a problem if the person has a really specific taste for women and men, but i do see a problem when the person starts to get in bad situations and mood due to this confusion
I personally had the same situation during the quarantine, since all my contact with girls was with messages and most of them used anime or popular media characters profile pictures, but it changed as soon as i returned to my daily life of going out to work and study since i had to talk and deal with real women and etc, i think this kind of situation can happen due to 2 things:
Way too much media consume;
Way too little contact with real people.
I experienced both at the same time and tbh, it is a situation that you can get over easily if you talk more to real people and consume more media that has real people instead of too much fictional media, but it depends if you can deal with this situation without problems or not, but well, at least for me, having more contact with real people helped in only some days
I don't think is a problem if you can't describe how a real girl is since there's a lot of kinds and all them are different to each other in their ways, different to describing anime women since they usually has several similar features and details